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Backgrounds
The Sertoli cell that plays a vital role during spermatogenesis is a known target of physiological and pathological factors affecting testicular development. Tumor necrosis factor alpha (TNFα) participates in the blood–testis barrier reconstruction, cell apoptosis, and inflammatory response by recognizing receptors on Sertoli cell. TNFα has also been shown to induce the proliferation...
Purpose
Testosterone deficiency and changes in testosterone levels are important in men's health and may be associated with fat accumulation. In order to investigate the connection between testosterone and fat accumulation in adult males, we employed lipid accumulation product and compared it to triglyceride–glucose and Homeostasis Model Assessment of Insulin Resistance.
Materials and methods
An...
Introduction
Penile and genital surgery for congenital or acquired conditions is daily practice in reconstructive urology. These procedures, which carry the risk of disrupting nerves and blood vessels, may impair the genital sensation, and affect the capacity for sexual pleasure. Self‐reported tools are needed to systematically assess the male genitalia before and after reconstructive surgeries in...
Objective
Follicle‐stimulating hormone (FSH) receptor expression has been reported in many extra‐gonadal tissues, raising the question of non‐reproductive effects of FSH. Because of increasing usage of FSH in treatment of male infertility, deeper knowledge of possible harmful off‐target effects of FSH is warranted.
Methods
In total, 33 healthy young men (mean age 30 years) were included in the...
Background
The mechanism of high‐fat diet (HFD)‐induced decrease in erectile function has not been elucidated, and in previous studies, spectrin alpha, erythrocytic 1 (SPTA1) is a cytoskeletal protein that regulates cellular function, which belongs to a family of proteins that can affect cell and tissue growth and development by regulating YAP, an effector on the Hippo signaling pathway, but its...
Background
Intracellular levels of cyclic nucleotides can also be controlled by the action of multidrug resistance protein types 4 (MRP4) and 5 (MRP5). To date, no studies evaluated the role of their inhibition in an animal model of erectile dysfunction (ED).
Objectives
To evaluate the effect of a 2‐week treatment with MK571, an inhibitor of the efflux of cyclic nucleotides in the ED of obese mice...
Background
According to current guidelines, confirmation that vasectomy results in sterility depends on microscopic examination of postvasectomy semen for the presence of spermatozoa. Guidelines established in 2012 require examination of a fresh specimen within 2 h of collection, which necessitates the patient making an appointment with either the surgeon's office or a licensed clinical laboratory...
Background
Due to the heterogeneous distribution of seminiferous tubules (STs) in patients with nonobstructive azoospermia (NOA), retrieving enough good quality spermatozoa for ICSI may require a complete testicular dissection. According to the only available study in this field, spermatozoa may be found in the testis surface in 34.2% of patients, while a deeper testicular dissection is able to provide...
Background
Premature ejaculation (PE) is the most common ejaculatory function disorder. To date, four types of PE have been identified depending on the severity, onset, and course of the problem.
Objectives
The aim of this study was to investigate whether or not there is a difference between these types in respect of anxiety, perceived stress, insomnia severity, and sleep chronotype.
Materials...
Background
Despite growing evidence suggesting age‐related molecular changes in gametes, the impact of paternal age on clinical outcomes during infertility treatments has not been adequately assessed.
Objectives
This study aims to assess the correlation of paternal age to clinical pregnancy and live birth rates in egg donation cycles undergoing intracytoplasmic sperm injection.
Materials and...
Background
Poor male fecundity is of concern, and a prenatal origin has been proposed. Folate, a methyl donor involved in DNA methylation, is essential for normal fetal development by regulating gene expression during different periods of fetal development. Thus, prenatal exposure to low maternal folate intake might have a programing function of the developing reproductive organs.
Objectives
To...
Background
Particulate matter (PM), including PM2.5 (PM ≤ 2.5 µm in aerodynamic diameter) and PM10 (PM ≤ 10 µm in aerodynamic diameter), is a component of air pollutants, which is linked to semen quality. However, the available evidence of association needs to be strengthened, and some studies have conflicting results.
Objectives
To evaluate the potential impacts of PM on semen quality during the...
The US Supreme Court decision against abortion has once again triggered the call for male contraception. However, in addition to existing methods, there are further reasons why pharmacological reversible easy‐to‐use male contraception should be available. Green activists and environmentalists have to recognize that overpopulation consume resources. Medical progress results in increasing life expectancy...
Objectives
To assess the effectiveness of follicle‐stimulating hormone (FSH) administration in male idiopathic infertility in a clinical setting.
Methods
A retrospective real‐world study was carried out, including all consecutive FSH‐treated infertile men attending the Andrology Unit of Modena (Italy) from June 2015 to May 2022. Medical history, physical and andrological examinations, hormonal...
Background
Maternal fever during pregnancy has been associated with an increased risk of genital malformations, but the implication for long‐term reproductive health in the offspring is unknown.
Objectives
To investigate associations between timing, duration, and temperature of fetal exposure to maternal fever and sons’ semen quality, testicular volume, and levels of reproductive hormones in early...
Background
Peyronie's disease (PD) has a huge impact on patients’ physical and psychological wellbeing.
Objectives
To investigate whether patients’ age has an impact on PD symptomatic burden at first presentation.
Materials and methods
Data from 129 consecutive heterosexual patients seeking first medical attention for PD at a single andrological tertiary‐referral centre were collected. All patients...
Background
Men with Klinefelter Syndrome develop some degree of seminiferous tubule degeneration, hyalinization, and fibrosis by adulthood. However, the pathophysiology surrounding testicular fibrosis in Klinefelter Syndrome patients remains incompletely understood.
Objectives
To perform a systematic review of literature studying the mechanisms of fibrosis initiation or propagation in Klinefelter...
Background
Testicular function, including compensated Leydig cell function, has been indicated to be an early marker of morbidity.
Objective
To study the association of testicular function and markers of metabolic and cardiovascular health in a population of young men.
Materials and methods
A cross‐sectional study of 2289 men (median age 19 years, 5–95 percentile 18.4–22.2) from the general population...
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